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Video Abstract (AI generated) (01:03) Paper PreprintThe human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domain, previously C6orf106) is a recently-characterised inhibitor of the transcription regulators p300 and CREB-binding protein (CBP). Here we have utilised RNA-seq to define cellular pathways regulated by ILRUN in the context of severe acute respiratory syndrome -associated coronavirus-2 (SARS-CoV-2) infection. We find that inhibition of ILRUN expression increases cellular expression of several members of the renin-angiotensin aldosterone system (RAAS), including the SARS-CoV-2 entry receptor angiotensin converting enzyme 2 (ACE2). Furthermore, inhibition of ILRUN results in increased SARS-CoV-2 replication. These data identify ILRUN as a novel inhibitor of SARS-CoV-2 replication and represents, to our knowledge, the first report of ILRUN as a regulator of the RAAS.
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Leon Tribolet. (2021, Nov 6).ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2[Video]. Scitok. https://scitok.com/project/p/ed158b89
Tribolet Leon. "ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2" Scitok, uploaded by Tribolet Leon, 6 Nov, 2021, https://scitok.com/project/ped158b89
Leon Tribolet. "ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2" Scitok. (Nov 6, 2021). https://scitok.com/project/p/ed158b89
Leon Tribolet (Nov 6, 2021). ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2 Scitok. https://scitok.com/project/p/ed158b89
Leon Tribolet. ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2[video]. 2021 Nov 6. https://scitok.com/project/p/ed158b89
@online{al2006link, title={ ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2 }, author={ Tribolet, Leon }, organization={Scitok}, month={ Nov }, day={ 6 }, year={ 2021 }, url = {https://scitok.com/project/p/ed158b89}, }