Author(s)
Loren Frank
Professor at University of California, San Francisco
Field of Study: Biology , Published 30 Projects
Animal Behavior And Cognition Real Time Sharp Wave Ripple Theta Oscillations Public Speaking
Content
Video Abstract (AI generated) (01:14) Paper PreprintSpecific classes of GABAergic neurons are thought to play specific roles in regulating information processing in the brain. In the hippocampus, two major classes - parvalbumin-expressing (PV+) and somatostatin-expressing (SST+) neurons - differentially regulate endogenous firing patterns and target different subcellular compartments of principal cells, but how these classes regulate the flow of information throughout the hippocampus is poorly understood. We hypothesized that PV+ and SST+ interneurons in the dentate gyrus (DG) and CA3 might differentially modulate CA3 patterns of output, thereby altering the influence of CA3 on CA1. We found that while suppressing either interneuron type increased DG and CA3 output, the effects on CA1 were very different. Suppressing PV+ interneurons increased local field potential signatures of coupling from CA3 to CA1 and decreased signatures of coupling from entorhinal cortex to CA1; suppressing SST+ interneurons had the opposite effect. Thus, DG and CA3 PV+ and SST+ interneurons bidirectionally modulate the flow of information through the hippocampal circuit.
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Yadong Huang. (2021, Nov 4).Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1[Video]. Scitok. https://scitok.com/project/p/ee1ea84e
A. Aery Jones Emily. "Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1" Scitok, uploaded by Huang Yadong, 4 Nov, 2021, https://scitok.com/project/pee1ea84e
Yadong Huang. "Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1" Scitok. (Nov 4, 2021). https://scitok.com/project/p/ee1ea84e
Yadong Huang (Nov 4, 2021). Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1 Scitok. https://scitok.com/project/p/ee1ea84e
Yadong Huang. Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1[video]. 2021 Nov 4. https://scitok.com/project/p/ee1ea84e
@online{al2006link, title={ Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1 }, author={ Huang, Yadong }, organization={Scitok}, month={ Nov }, day={ 4 }, year={ 2021 }, url = {https://scitok.com/project/p/ee1ea84e}, }