Biochemistry - SciTok - SciTok

Biochemistry 38 Projects

Structure, Mechanism and Crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Joseph A Newman

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A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

Yudao Shen

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A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

Xiao-Chuan Cai

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A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

Sumera Perveen

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A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

Aliakbar Khalili Yazdi

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Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

Kanchan Devkota

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A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

Sebastian Scheer

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Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Magda Szewczyk

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Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells

Shane Miersch

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Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Glycopeptide Data

Rebeca Kawahara

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Priming mycobacterial ESX-secreted protein B to form a channel-like structure

Abril Gijsbers

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Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

Estella A. Newcombe

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Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

Xiaojing Sui

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Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

Mona Radwan

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A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells

Candice B. Raeburn

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Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

Mona Radwan

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Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture

Khushboo Bafna

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Conductance mechanisms of rapidly desensitizing cation channelrhodopsins from cryptophyte algae

Oleg A. Sineshchekov

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Cation and anion channelrhodopsins: Sequence motifs and taxonomic distribution

Elena G. Govorunova

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Crystal Structure of a Natural Light-Gated Anion Channelrhodopsin

Hai Li

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RubyACRs, non-algal anion channelrhodopsins with highly red-shifted absorption

Elena G. Govorunova

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The photoactive site modulates current rectification and channel closing in the natural anion channelrhodopsin GtACR1

Oleg A. Sineshchekov

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The bacterial DNA binding protein MatP involved in linking the nucleoid terminal domain to the divisome at midcell interacts with lipid membranes

Begoña Monterroso

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Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB

Danguole Kureisaite-Ciziene

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A Novel Process Maintaining Glycerophospholipid Homeostasis in Mammalian Cells

Martin Hermansson

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Partial spontaneous intersubunit rotations in actively translating ribosomes

Tianhan Huang

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RACK1 on and off the ribosome

Alex G. Johnson

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eIF5B gates the transition from translation initiation to elongation

Jinfan Wang

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Directed evolution reveals the mechanism of HitRS signal transduction in Bacillus anthracis

Hualiang Pi

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Hepcidin and conventional markers to detect iron deficiency in severely anaemic HIV-infected patients in Malawi

Minke HW Huibers

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Mechanisms of γ-Secretase Activation and Substrate Processing

Apurba Bhattarai

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Ligand Gaussian accelerated molecular dynamics (LiGaMD): Characterization of ligand binding thermodynamics and kinetics

Yinglong Miao

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Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)

Chul-Hwan Lee

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NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain

Sanxiong Liu

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A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

Havva Ortabozkoyun Kara

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Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

Chul-Hwan Lee

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Active and repressed chromatin domains exhibit distinct nucleosome segregation during DNA replication

Thelma M. Escobar

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Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

Chul-Hwan Lee

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